Lab-on-Skin™ Technology

LEVERAGING SEMICONDUCTORS FOR HIGH SENSITIVITY AND EXTREME MINIATURIZATION

AT THE CROSSROADS OF ADVANCED NANOTECH AND BIOCHEMISTRY

Pushing the Boundaries of Wearable Sensing

At Xsensio, we go beyond physical activity tracking to unlock a new dimension of wearable technology: real-time biochemical sensing directly on the skin. Our breakthrough Lab-on-Skin© sensing chip analyzes biomarkers in the interstitial fluid (ISF) — the body’s natural window into inflammation, metabolism, and organ function. By combining nanotechnology, biochemistry, and microfluidics, we detect subtle physiological changes as they happen, providing continuous insight into the body’s internal state.

Designed for multiparametric analysis, our ultra-miniaturized chip integrates multiple sensors targeting a range of biomarkers — from metabolites and ions to proteins and hormones. Its modular and customizable architecture enables us to adapt the same platform across diverse clinical use cases. All data is made securely available in real time to patients, caregivers, or healthcare providers, enabling earlier interventions and more personalized care.

A Configurable Sensing Platform for Diverse Applications

Depending on the targeted use case, the Lab-on-Skin™ chip can be configured with a specific set of biochemical sensors. This enables application-specific sensing, from ICU shock monitoring to inflammation detection in oncology and surgical recovery.

Xsensio is developing a scalable and proprietary platform of wearable products and services, all built on our core Lab-on-Skin™ system. Each solution combines:

Our customized multi-sensor chip
A proprietary skin interface
Wireless communication for on-demand or continuous data streaming

For each clinical or wellness application, we develop — independently or in partnership — a tailored data analytics tool to convert raw sensor data into meaningful, actionable insights.

Recent publications

Sheibani, S., Capua, L., Kamaei, S. et al. Extended gate field-effect-transistor for sensing cortisol stress hormone. Commun Mater 2, 10 (2021). https://doi.org/10.1038/s43246-020-00114-x

Zhang, Junrui; Rupakula, Maneesha; Bellando, Francesco; Garcia Cordero, Erick; Longo, Johan; Wildhaber, Fabien; et al. (2019): Sweat Biomarker Sensor Incorporating Picowatt, Three-Dimensional Extended Metal Gate Ion Sensitive Field Effect Transistors. ACS Publications. Collection.
https://doi.org/10.1021/acssensors.9b00597

Garcia-Cordero E, Bellando F, Zhang J, Wildhaber F, Longo J, Guérin H, Ionescu AM. Three-Dimensional Integrated Ultra-Low-Volume Passive Microfluidics with Ion-Sensitive Field-Effect Transistors for Multiparameter Wearable Sweat Analyzers.

ACS Nano. 2018 Dec 26;12(12):12646-12656. https://pubs.acs.org/doi/10.1021/acsnano.8b07413